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dr. A.M.G. (Annette) Dirac

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Visiting address
  • Science Park 904
  • Room number: B0.160
Postal address
  • Science Park 904
    1098 XH Amsterdam
Contact details
  • Profile

    Annette Dirac studied Biology at the University of Aarhus, Denmark and also obtained her PhD from there with a thesis regarding aspects of the molecular biology of the Human Immunodeficiency Virus (HIV). Following this she worked as a researcher at the Netherlands Cancer Institute, focusing on genetic screening to identify new genes involved in cancer development, and managing her group’s participation in a European Network of Excellence from 2007 - 2011. Annette joined a grant advising agency for a year and a half, gaining vast experience in EU grant applications. She also supported a range of Dutch grant applications, and was involved in the project management of multi-partner EU projects. Annette has been working as an advisor research funding at the Technology Transfer Office since July 2013. 

     

  • Publications

    Peer-reviewed articles

     

    Kuiken HJ, Egan DA, Laman H, Bernards R, Beijersbergen RL, Dirac AM. Identification of F-box only protein 7 as a negative regulator of NF-kappaB signaling. J cell Mol Med, 2012 Sep;16(9):2140-9.

     

    Eichhorn PJA, Rodón L, Gonzàlez-Juncà A, Dirac AM, Gili M, Martínez-Sáez E, Aura C, Barba I, Prat A, Cuartas I, Jimenez J, García-Dorado D, Bernards R, Baselga J, Seoane J. USP15 stabilizes the TGFb receptor I and is responsible for the hyperactivation of the TGFb signal in glioblastoma. Nat Med. 2012 Feb 19;18(3):429-35.

     

    Faesen AC, Dirac AM, Shanmugham A, Ovaa H, Perrakis A, Sixma TK. Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain (HUBL) and allosteric regulation by GMP-synthetase. Mol. Cell, 2011 Oct 7;44(1):147-59.

     

    Moretti J, Chastagner P, Gastaldello S, Heuss S, Dirac AM, Bernards R, Masucci M, Israel A, and Brou C. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. PLoS Biol. 2010 Nov 23;8(11):e1000545.

     

    Dirac AM, Bernards R. The deubiquitinating enzyme USP26 is a regulator of Androgen Receptor signaling. Mol Cancer Res. 2010 Jun 8(6):844-54.

     

    Naarding MA, Dirac AM, Ludwig IS, Speijer D, Lindquist S, Vestman EL, Stax MJ, Geijtenbeek TB, Pollakis G, Hernell O, Paxton WA. Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells. Antimicrob Agents Chemother. 2006 Oct;50(10):3367-74.

     

    Oosterkamp HM, Neering H, Nijman SM, Dirac AM, Mooi WJ, Bernards R and Brummelkamp TR. An Evaluation of the Efficacy of Topical Application of Salicylic Acid for the Treatment of Familial Cylindromatosis. Br.J.Derm. 2006, jul;155(1):182-5.

     

    Nijman SM*, Huang T*, Dirac AM*, Brummelkamp TR, Kerkhoven RM, D’Andrea AD, Bernards R. The de-ubiquitinating enzyme USP1 regulates the Fanconi Anemia pathway. Mol Cell. 2005 Feb 4;17(3):331-9.

     

    Brummelkamp TR*, Nijman SM*, Dirac AM*, Bernards R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature. 2003 Aug 14;424(6950):797-801.

     

    Dirac AM, Bernards R. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem. 2003 Apr 4;278(14):11731-4.

     

    Dirac AM, Huthoff H, Kjems J, Berkhout B. Requirements for RNA-heterodimerization of the HIV-1 and HIV-2 genomes. J Gen Virol. 2002 Oct;83(Pt 10):2533-42.

     

    Dirac AM, Huthoff H, Kjems J, Berkhout B. Regulated HIV-2 RNA Dimerization by means of Alternative RNA Conformations. Nucleic Acids Res. 2002 Jun 15;30(12):2647-55..

     

    Dirac AM, Huthoff H, Kjems J, Berkhout B. The Dimer Initiation Site Hairpin Mediates Dimerization of the Human Immunodeficiency Virus Type 2 RNA Genome. Jour. Biol. Chem. 2001, 276: 32345-52.

     

    Dirac AM & Kjems J. Mapping DNA binding sites of HIV 1 integrase by protein footprinting. Eur. J. Biochem. 2001, 268: 743-51.

     

    Otero G, Fellows J, Li Y, de Bizemont T, Dirac AM, Gustafsson CM, Erdjument-Bromage H, Tempst P, Svejstrup JQ. Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol. Cell 1999 Jan;3(1):109-18.

     

    * These authors contributed equally

    Reviews 

     

    Dirac AM & Bernards R. Functional identification of critical targets of the Ubiquitin-Proteasome pathway. ASCO 2007 Educational book: 699-703.

     

    Dirac AM, Nijman SM, Brummelkamp TR , Bernards R. Functional annotation of de-ubiquitinating enzymes using RNA interference. Methods in Enzymology, 2005;398:554-67.

     

    Nijman SM, Luna-Vargas MP, Velds A, Brummelkamp TR, Dirac AM, Sixma TK, Bernards R. A genomic and functional inventory of deubiquitinating enzymes. Cell. 2005 Dec 2;123(5):773-86.

     

  • Ancillary activities
    • No ancillary activities
    • European Commission, Brussels
      Expert evaluator